Naltrexone Effectiveness - Alcohol's Effects in the Brain
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Alcohol can make you laugh or it can make you cry, it can make you thoughprovoking or make you sleepy, it can boost your reliance or make you act the fool. How can alcohol have all these different effects on people? If we want to know how alcohol affects our moods and behaviors we must first understand a bit about how the brain works.
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The human brain is made up of about 100 billion nerve cells (also known as neurons). Everything that we think, feel or do is the result of electrical signals passing back and forth in the middle of neurons. These electrical signals wish the help of chemicals called neurotransmitters in order to pass from neuron to neuron. Scientists have identified nearby 60 different neurotransmitters so far and tell us that there are probably many more yet to be identified.
Different neurotransmitters have different effects in the brain. For example, serotonin is associated with mood. Population suffering from clinical depression tend to have a shortage of serotonin in their brains, and medications like Prozac can help to alleviate depression by addition the availability of serotonin in the brain. Endorphins are a class of neurotransmitters which act as the brain's natural painkillers.
Electrical signals in the brain are transmitted in the following manner: The neuron which is sending the electrical signal releases a neurotransmitter, and the neuron which is receiving the electrical signal accepts the neurotransmitter at a site which is called a receptor. When the neurotransmitter from the first neuron chemically binds to the receptor of the second neuron the electrical signal is transmitted. Neurotransmitters and receptors work like locks and keys: there is at least one different receptor for each different neurotransmitter. For example, an endorphin receptor can only be triggered by and endorphin, a serotonin receptor can only be triggered by serotonin, and so on. different neurons have different receptors. Some neurons will only be triggered by serotonin, some only by an endorphin, and so on for all the different neurotransmitters.
Okay--now what does all of this have to do with alcohol?
Every mood altering substance from heroin to coffee has an result on the neurotransmitter theory of the brain. Some psychoactive drugs work on only one exact neurotransmitter system, whereas others work on many. Morphine, for example, mimics the neurotransmitter beta-endorphin--a natural painkiller found in the brain. Morphine is shaped like beta-endorphin and binds to the beta-endorphin receptors thus acting as a painkiller and also giving rise to feelings of pleasure. Caffeine is shaped like Adenosine and acts on the adenosine receptors. Alcohol on the other hand affects many different neurotransmitters, not just one, Why is this?
Morphine and caffeine are both large molecules. Neurotransmitters are also large molecules. Morphine and caffeine have the effects which they do because of their similarity in shape to neurotransmitters which occur simply in the brain. Alcohol on the other hand is a quite small molecule. Alcohol does not mimic a neurotransmitter. So then how does alcohol work on neurotransmitters?
Alcohol is a fat soluble molecule. Fats (called lipids) are a major component of all cell membranes, including the cell membranes of neurons. Alcohol enters the cell membranes of neurons and changes their properties. Receptors are settled on cell membranes and this means that receptor properties are altered by the presence of alcohol. Cell membranes also operate the publish of neurotransmitters and this means that the publish of neurotransmitters is also affected by the presence of alcohol.
The effects of alcohol on receptors and neurotransmitters have been well documented for several neurotransmitters and their corresponding receptors. These effects are summarized in Table 1.
Table 1: Alcohol's result on Neurotransmitters and Receptors
Glutamate
Alcohol inhibits glutamate receptor function
This causes muscular relaxation, discoordination, slurred speech, staggering, memory disruption, and blackouts
Ether and chloroform have similar effects on the glutamate system
Alcohol enhances Gaba receptor function
This causes feelings of calm, anxiety-reduction and sleep
Valium has a similar result on the Gaba system
Alcohol raises dopamine levels
This leads to excitement and stimulation
Cocaine and amphetamine have similar effects on the dopamine system
Alcohol raises endorphin levels
This kills pain and leads to an endorphin "high"
Morphine and heroin have similar effects on the endorphin theory
Drugs like morphine or cocaine have been referred to as "chemical scalpels" because of their very strict effects on just one neurotransmitter system. Alcohol on the other hand is much more like a chemical hand grenade in that it affects just about all parts of the brain and all neurotransmitter systems. Alcohol affects all these systems at the same time. When Population drink alcohol they come to be thoughprovoking and excited because alcohol raises dopamine levels just as cocaine does, although alcohol does not raise dopamine levels in any place near as much as cocaine does. When Population drink alcohol they feel calm and lose their anxieties because alcohol makes the Gaba receptors function more efficiently just like valium does. The reason that Population tend to fall asleep after drinking alcohol or taking valium is also due to this result on the Gaba receptor. And alcohol has a painkilling result like morphine and produces a high similar to morphine because it causes a publish of endorphins into the brain thus raising the endorphin levels. (Note that the result of morphine is different from alcohol in its mechanism--morphine imitates endorphins and binds to endorphin receptors whereas alcohol increases the amounts of the endorphins in the brain.) ultimately we come to glutamate. Alcohol greatly inhibits the functioning of the glutamate receptor. Glutamate is responsible for the formation of new memories as well as for muscular coordination. It is alcohol's result on the glutamate receptor which leads to slurred speech, and startling in Population who have consumed alcohol, as well as the inability to remember what one did that night when the morning after comes. Possibly the only obvious result of this result on the glutamate receptor is a feeling of muscular relaxation. Many negative effects of alcohol such as automobile fatalities due to drunk driving are the result of the loss of coordination caused by alcohol's result on the glutamate receptor. Even small amounts of alcohol have a major impact on coordination--so never, never drink and drive.
You have probably observed that alcohol seems to have different effects on different people. Some Population speedily come to be sleepy after drinking just a little alcohol whereas others come to be thoughprovoking and want to just go, go, go. Research on mice suggests that this variation is genetic. Scientists have been able to breed strains of mice which speedily go to sleep after ingesting alcohol. They have also been able to breed strains of mice which come to be very active after ingesting alcohol. This strongly suggests that genetics determines which neurotransmitter theory is most strongly affected by alcohol in which individual. Individuals who come to be sleepy soon after drinking probably have their Gaba theory more strongly affected by alcohol. And individuals who come to be thoughprovoking and excited after drink probably have their dopamine theory most strongly affected.
The effects of alcohol on the brain do not end when alcohol is fully metabolized and out of the system--what happens next is something called neurotransmitter rebound. This rebound result is most certainly visible if we look at what happens to many Population when they use a drink or two as a sleep aid. These Population often tend to wake up in the middle of the night and find themselves unable to fall back asleep. What is happening is this--alcohol has enhanced the functioning of the Gaba theory and has made these Population feel relaxed and sleepy. The entire time that alcohol is present the Gaba theory is struggling to overcome the effects of alcohol and return to normal functioning. When all the alcohol is ultimately out of the body, the Gaba theory overshoots the mark and leaves Population feeling restless and wide awake. This is why alcohol is not a good sleep aid. Large quantities of alcohol can keep a person asleep longer, but drinking large quantities of alcohol has its own negative effects. Neurotransmitter rebound seems also to be concerned in symptoms of hangovers such as hyper-sensitivity to light and in alcohol seclusion syndrome giving rise to feelings of anxiety and panic and other symptoms as well.
Some medications used to treat alcohol abuse such as campral and naltrexone work by affecting the neurotransmitter systems. Naltrexone (also called revia) is an opioid receptor antagonist. Naltrexone works by binding to the endorphin receptors (which are sometimes also called opioid receptors) and blocking them off so that opiates cannot bind to these receptors. Unlike opiates or endorphins naltrexone has no painkilling effects and no pleasurable effects. Naltrexone simply blocks off the endorphin receptors so that neither opiates nor endorphins can have their painkilling or pleasurable effects. Naltrexone is very sufficient with Population who use opiates such as morphine or heroin since these drugs have no result at all when the receptors are blocked by naltrexone. Naltrexone has some result in helping Population to abstain from alcohol or to moderate their use, however it is not as sufficient with alcohol as with opiates because alcohol affects many different neurotransmitters. The downside of naltrexone is that the body's natural painkillers, the endorphins, are unable to do their job when it is present. Population taking naltrexone are advised to wear medic-alert bracelets so that doctors will know that painkillers are ineffective on these people.
Campral (also known as acamprosate) is a glutamate receptor modulator. Campral helps eliminate cravings for alcohol in long term heavy drinkers. It is hypothesized that long term heavy drinking upsets the glutamate neurotransmitter theory and that campral helps to restore this to normal.
No discussion of alcohol and the brain would be faultless without a mention of potential brain damage caused by alcohol abuse. It is likely that we have all heard that drinking kills brain cells. However, does scientific evidence bear out this coarse folk saying? A 1993 study by Jensen and Pakkenberg published in Lancet titled "Do alcoholics drink their neurons away?" compared the brains of alcoholics to the brains of non-alcoholics. This study found that the white matter of the brains of alcoholics was significantly depleted. The gray matter, however, was the same in both alcoholics and non-alcoholics. This is thoughprovoking since it is the gray matter that does the thinking. The gray matter has been compared to a network of computers, and the white matter to the cables linking them together. The brain does not produce new gray matter to replace that which is lost. The brain can, however, produce new white matter to replace white matter which has been lost. The researchers accomplished that loss of white matter do to heavy drinking may Possibly not constitute irreparable damage.
There is, however, a form of irreparable brain damage which can be caused by long term heavy drinking. This is Wernicke-Korsakoff Syndrome, also known as "wet brain". Wernicke-Korsakoff Syndromeis not caused by a loss of brain cells--it is caused by a scantness of vitamin B1 (also known as thiamine). Wernicke-Korsakoff Syndrome can have several causes including ultimate malnutrition, continued periods of vomiting due to morning sickness or an eating disorder, kidney dialysis, stomach stapling, or alcohol abuse. The vast majority of cases of Wernicke-Korsakoff Syndrome which occur in the United States are caused by severe, long-term, heavy drinking. Alcohol can lead to Wernicke-Korsakoff Syndrome because it blocks the absorption of thiamine. Symptoms of Wernicke-Korsakoff Syndrome comprise amnesia, inability to form new memories, confusion, hallucinations, and confabulation. Some of the more severe symptoms of Wernicke-Korsakoff Syndrome can be treated with thiamine, however in most cases many of the symptoms persist for a lifetime.
Have scientists discovered Everything that there is to know about alcohol's effects on the brain? It seems that this is clearly not the case. Scientists believe that alcohol likely affects many more neurotransmitters than the four discussed in this article. There is constant and ongoing Research to explore how alcohol might work on other neurotransmitters. The time to come is likely to bring us much new knowledge about alcohol and the brain.
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